Monday, August 10, 2009

CD36 Peptides That Block Cytoadherence Define the CD36 Binding Region

Cell adhesion interactions are important in the understanding of various cellular processes where specific recoggition of proteín surfaces is required. Erythrocytes parasitized (PE)by P. Falciparum segregate/sequester themselves, from the circulation by adhering to microvascular endothelial cells (MEC). This segregation contributes directly to the virulence and severe pathology of malaria derived from P. falciparum; it is known that cell surface protein CD36 is an important host receptor for PE adherence, and this adhesion is mediated by the malarial variant antigen, P. falciparum erythrocyte membrane protein 1 (PfEMP1) and also by its cysteine-rich interdomain region 1 (CIDR-1). A group of peptides from the immunodominant domain of CD36 (residues 139-184) ranging in sizes from 17 to 29 amino acids, interfered with the CD36-PfEMP1 protein-protein interaction. All these peptides diminished binding at low micromolar range. Two such peptides, CD36 145-171 and CD36 156-184, selectively blocked PE adhesion to CD36 with no effect on its binding to the host receptor intercellular adhesion molecule-1 (ICAM-1).It is also described that an adhesion blocking peptide from the ICAM-1 sequence interferes with PfEMP1â€" ICAM-1 interaction with no effect on its adhesion to CD36. These experiments validate earlier evidence that PfEMP1 is also a receptor for ICAM.In summary it is shown that region 139-184 ,comprise the binding/adhesion for P. falciparum. These peptides can be be very useful for understanding the PE/PfEMP1 interaction with CD36 and for possible development of anti-adhesion molecular therapies. --url: www.biosyn.comsite_owner: Jessica Castroaddress: 612 E. Main street city: Lewivillestate: Texascountry: USApostal_code: 75057phone_number: 972-420-8505Source:

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